论文部分内容阅读
目的：探讨Ⅰ期子宫内膜癌ｐ２１ｒａｓ 表达及ＤＮＡ 含量。方法：ＡＢＣ免疫组化法及流式细胞术。结果：随组织学分级增高ｐ２１ｒａｓ表达率增高（Ｐ＜ ０．０５），ＤＮＡ 异倍体率亦增加（Ｐ＜ ０．０５）。异倍体子宫内膜癌中ｐ２１ｒａｓ阳性表达率（８２．３５％ ）较二倍体子宫内膜癌（３０．７７％ ）高（Ｐ＜ ０．０５）。结论：提示ｐ２１ｒａｓ作为子宫内膜癌预后参数的可能性，尤其是双参数同步分析将更好地评价子宫内膜癌预后
Objective: To investigate the expression and DNA content of p21ras in stage Ⅰ endometrial carcinoma. Methods: ABC immunohistochemistry and flow cytometry. Results: With the increase of histological grade, the expression of p21ras increased (P <0.05) and the rate of DNA aneuploidy increased (P <0.05). The positive rate of p21ras expression in aneuploid endometrial carcinoma (82.35%) was higher than that in diploid endometrial carcinoma (30.77%) (P <0.05). CONCLUSIONS: The possibility of p21ras being a prognostic parameter for endometrial cancer is implicated, and in particular the two-parameter synchronous analysis will better evaluate the prognosis of endometrial cancer