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目的:探讨急慢性肝病患者肝组织损害与血清C_3氨基端肽(P(?)P)和层粘素(LN)水平的关系。方法:采用放射免疫法测定了110例急、慢性乙型肝炎患者的血清P(?)P和LN水平,并与肝组织病理损害程度进行对比分析。结果:急性组和慢性轻度组与正常对照组比较其血清P(?)P和LN水平无显著性差异(P>0.05),而慢性中度、重度和肝硬变组与正常对照组、急性组和慢性轻度组比较差异显著(P<0.05或0.01);并且,慢性肝病肝纤维化程度越重其血清P(?)P和LN水平也明显升高(P<0.05或0.01)。此外,血清P(?)P、LN与胆红素(TBil)水平呈正相关((P<0.05或0.05).与白蛋白(A)、白/球比值(A/G)和凝血酶原活动度(PTA)呈负相关(P<0.05或0.01),而与血清丙氨酸转移醇(ALT)和γ球蛋白(γ—G)不相关(P>0.05)。结论:测定血清P(?)P和LN水平对判断慢性肝痛肝组织的炎症坏死活动程度和肝纤维化程度有较大的参考价值。
Objective: To investigate the relationship between liver damage and the level of C_ (3) aminoterminal peptide (P_ (?) P) and laminin (LN) in patients with acute and chronic liver diseases. Methods: The serum levels of P (P) and LN in 110 patients with acute and chronic hepatitis B were determined by radioimmunoassay and compared with those of liver tissue. Results: There was no significant difference in serum P (P) and LN levels between acute group and chronic mild group and normal control group (P> 0.05) There was significant difference between the acute group and the chronic mild group (P <0.05 or 0.01). And, the severity of liver fibrosis in chronic liver disease was also significantly increased (P <0.05 or 0.01). In addition, there was a positive correlation between serum P (P) LN and TBil level (P <0.05 or 0.05), and albumin (A), white / (P <0.05 or 0.01), but not with serum ALT and γ-G (P> 0.05) .Conclusion: The serum P (? ) P and LN levels have a great reference value for judging the activity of liver inflammation and necrosis and the degree of liver fibrosis in patients with chronic hepatic pain.