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肝纤维化是所有慢性肝病向肝硬变发展的必经病理过程，其特点是细胞外基质（ＥＣＭ）的异常增多、沉积．ＥＣＭ的主要成分有胶原和弹性蛋白等纤维性蛋白质、非胶原糖蛋白及蛋白多糖．特别以Ⅰ，Ⅲ型胶原、糖蛋白及蛋白多糖增多明显．现已证明，Ｉｔｏ细胞是细胞外基质的主要细
Liver fibrosis is a pathological process in which all chronic liver diseases develop into cirrhosis and is characterized by an abnormal increase in extracellular matrix (ECM) deposition. The main components of ECM are fibrillar proteins such as collagen and elastin, non-collagen glycoproteins and proteoglycans. In particular, Ⅰ, Ⅲ collagen, glycoproteins and proteoglycan increased significantly. It has been demonstrated that Ito cells are the major fine of the extracellular matrix