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目的:探究α-硫辛酸联合前列地尔对早期糖尿病肾病患者疗效的影响。方法:选择2015年4月-2016年3月早期糖尿病肾病患者60例,随机分为两组,观察组接受α-硫辛酸联合前列地尔治疗,对照组接受α-硫辛酸治疗,比较两组患者治疗4周后的疗效及治疗前后空腹血糖、24小时尿微量蛋白排泄量、血肌酐含量。结果:治疗4周后,观察组总有效率(90.0%),对照组为(70.0%)(p<0.05);观察组患者的空腹血糖、24小时尿微量蛋白排泄量、血肌酐均低于对照组,差异有统计学意义(p<0.05)。结论:α-硫辛酸联合前列地尔治疗早期糖尿病肾病相比α-硫辛酸单独治疗,可有效改善患者临床症状及疗效。
Objective: To investigate the effect of α-lipoic acid combined with alprostadil on patients with early diabetic nephropathy. Methods: From April 2015 to March 2016, 60 patients with early diabetic nephropathy were randomly divided into two groups. The observation group received α-lipoic acid combined with alprostadil, while the control group received α-lipoic acid. Compared the two groups The curative effect of patients after 4 weeks and fasting blood glucose before and after treatment, 24-hour urinary protein excretion, serum creatinine. Results: After 4 weeks of treatment, the total effective rate (90.0%) in the observation group was (70.0%) (p <0.05). The fasting blood glucose, 24-hour urine microalbumin excretion and serum creatinine in the observation group were lower than those in the control group Control group, the difference was statistically significant (p <0.05). CONCLUSION: Alpha-lipoic acid combined with alprostadil is effective in amelioration of clinical symptoms and efficacy in patients with early diabetic nephropathy compared with alpha-lipoic acid alone.