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目的 探讨瘦素和胰岛素样生长因子-I(IGF-I)在糖尿病视网膜病变(DR)发病机制中的作用。方法 对57例2型糖尿病患者(按照DR分级标准,再将其分为3个亚组)及50例健康对照者,采用放射免疫法进行血清瘦素和IGF-I浓度的检测。 结果 糖尿病患者血清瘦素水平(8.8±3.4)ng／mL与健康对照者(8.5±2.5)ng／mL比较,差异无显著性(P>0.05);增生型糖尿病视网膜病变(PDR)患者15例,血清瘦素水平(12.5±2.5)ng／mL显著性高于非PDR患者,19例,(9.4±1.2)ng/mL(P<0.01)及无DR患者23例,(6.2±1.6)ng／mL(P<0.01);非PDR患者血清瘦素水平也显著性高于无DR(P<0.01)。糖尿病患者血清IGF-I水平(188±38)ng／mL与健康对照者(136±42)ng/mL比较,差异有显著性(P<0.05)。PDR血清IGF-I水平(228±31)ng／mL显著性高于非PDR(186±55)ng／mL(P<0.01)及无DR(156±37)ng／mL(P<0.01);非PDR血清IGF-I水平也显著性高于无DR(P<0.01)。 结论 血清瘦索及IGF-I与DR及其严重程度显著相关,两者在DR发病机制中可能发挥重要作用,但两者之间并无相关性。
Objective To investigate the role of leptin and insulin-like growth factor-I (IGF-I) in the pathogenesis of diabetic retinopathy (DR). Methods Serum leptin and IGF-I levels were measured by radioimmunoassay in 57 patients with type 2 diabetes mellitus (divided into 3 sub-groups according to DR classification criteria) and 50 healthy controls. Results There was no significant difference in the serum leptin levels between diabetic patients and those with healthy controls (8.8 ± 3.4 ng / mL vs 8.5 ± 2.5 ng / mL, P> 0.05) and in 15 patients with proliferative diabetic retinopathy (PDR) (12.5 ± 2.5) ng / mL were significantly higher than those in non-PDR patients (19 cases, 9.4 ± 1.2 ng / mL, P <0.01) / ML (P <0.01). The serum leptin levels in non-PDR patients were also significantly higher than those without DR (P <0.01). The serum IGF-I levels of diabetic patients (188 ± 38) ng / mL were significantly higher than those of healthy controls (136 ± 42) ng / mL (P <0.05). The serum level of IGF - I in PDR group was significantly higher than that of non - PDR group (228 ± 31) ng / mL (186 ± 55) ng / mL and no (156 ± 37) ng / mL; Non-PDR serum IGF-I levels were also significantly higher than those without DR (P <0.01). Conclusions Serum leptin and IGF-I are significantly correlated with DR and its severity, both of which may play an important role in the pathogenesis of DR, but there is no correlation between them.