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目的探讨单唾液酸四己糖神经节苷脂钠治疗突发性耳聋的疗效。方法将突发性耳聋患者80例随机分为治疗组和对照组,治疗组患者给予单唾液酸四己糖神经节苷脂钠静滴,对照组患者给予甲钴胺注射液静推,两组均同时行激素、扩血管药物、高压氧等治疗。10 d为一疗程。结果单唾液酸四己糖神经节苷脂钠组听力提高的总有效率为85%,痊愈率为52.5%;而对照组的总有效率为62.5%,痊愈率为27.5%,两组差异有统计学意义(P<0.05);治疗组耳鸣好转的总有效率为80%,对照组的总有效率为51.7%,两组差异有统计学意义(P<0.05)。结论单唾液酸四己糖神经节苷脂钠治疗突发性耳聋疗效相对于其他方法疗效较好。
Objective To investigate the therapeutic effect of monosialotetrahexosyl ganglioside on patients with sudden deafness. Methods Eighty patients with sudden deafness were randomly divided into treatment group and control group. Patients in the treatment group received intravenous administration of monosialotetrahexosyl ganglioside sodium, and patients in the control group received methylcobalamin injection. The patients in two groups All simultaneously hormone, vasodilator drugs, hyperbaric oxygen and other treatment. 10 d for a course of treatment. Results The total effective rate of hearing improvement in monosialotetrahexosyl ganglioside sodium group was 85% and the cure rate was 52.5%. The total effective rate in control group was 62.5% and the cure rate was 27.5% (P <0.05). The total effective rate of tinnitus improvement was 80% in the treatment group and 51.7% in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion The efficacy of monosialotetrahexosyl ganglioside in the treatment of sudden deafness is better than other methods.