The MLL family histone methyltransferases play an essential role in the maintenance of the histone H3 Lysine 4 (H3K4) methylation status for gene expression dur
Scaffold proteins are known to play critical roles in very diverse cellular processes including trafficking, anchoring and clustering of ion channels/receptors;
Bacterial pathogens inject virulent effector proteins into host cells to inhibit or manipulate host cellular processes.We previous demonstrates that these effec
The proteasomal ATPase ring, comprising Rpt1-Rpt6, associates with the heptameric α ring of the proteasome core particle (CP) in the mature proteasome, with th
Metabolic homeostasis is maintained by various cellular sensors, including the master kinases AMPK(AMP-activated protein kinase) and mTORC 1.In response to low