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采用免疫组织化学LSAB法对68例膀胱移行上皮癌标本中的抑癌基因p16表达产物进行检测，29例显示表达阳性，且阳性表达率在恶性度低、浅表性和未复发膀胱肿瘤中较高，Ⅰ级与Ⅱ级、Ⅰ级与Ⅲ级、Tis～T1与T2～T4、及复发与未复发比较均有显著性差异（P＜0．05）。表明p16蛋白表达与膀胱移行上皮癌的分化程度、浸润深度及预后有关。
Immunohistochemical LSAB method 68 cases of bladder transitional epithelial cancer specimens of tumor suppressor gene p16 expression was detected in 29 cases showed positive, and the positive expression rate in low grade, superficial and non-recurrent bladder tumor There was significant difference between high, grade Ⅰ and Ⅱ, grade Ⅰ and Ⅲ, Tis ~ T1 and T2 ~ T4, recurrence and no recurrence (P <0.05). The results showed that the expression of p16 protein was related to the differentiation, depth of invasion and prognosis of bladder transitional cell carcinoma.