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目的研究pAkt在肝细胞肝癌(HCC)中的表达及其与临床病理参数、预后之间的关系。方法利用组织芯片技术和免疫组化方法检测85例HCC组织、85例癌旁组织和26例正常肝组织中pAkt的表达情况,并分析其与临床病理参数和预后的关系。结果 pAkt在HCC中的表达阳性率(75.3%)高于癌旁组织(21.2%)(P<0.01)和正常肝组织(15.4%)(P<0.01),pAkt在HCC癌组织的表达与患者肿瘤转移有关,差异均具有统计学意义(P=0.007);pAkt阴性表达组(66.7%)生存率高于阳性表达组(35.9%),差异具有统计学意义(P=0.017)。结论 pAkt在HCC中过表达,在HCC的发生、发展、侵袭转移及预后中可能起重要作用。
Objective To study the expression of pAkt in hepatocellular carcinoma (HCC) and its relationship with clinicopathological parameters and prognosis. Methods The expression of pAkt in 85 cases of HCC, 85 cases of paracancerous tissues and 26 cases of normal liver tissues was detected by tissue microarray and immunohistochemistry. The relationship between pAkt and clinical pathological parameters and prognosis was analyzed. Results The positive expression rate of pAkt in HCC tissues was significantly higher than that in adjacent non-cancerous tissues (21.2%, P <0.01) and normal liver tissue (15.4%, P <0.01) (P = 0.007). The survival rate of pAkt-negative group (66.7%) was higher than that of positive expression group (35.9%), the difference was statistically significant (P = 0.017). Conclusion The overexpression of pAkt in HCC may play an important role in the occurrence, development, invasion, metastasis and prognosis of HCC.