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组合化学的出现使从天然产物发现新药被冷落了多年.实践证明,组合化学作为药物发现的工具还有待进一步发展和完善.天然产物在药物发现中的独特作用,近年来重新引起人们的关注.制药工业的决策者必须以新的观点,重新审视天然产物药物发现战略. 1.传统天然产物药物发现被冷落了多年近年来制药工业的新药产出率继续低落.造成这种状态的因素很多,一个原因可能是由于制药工业采用了新技术,特别是组合化学(combinatorial chemistry),而对天然产物药物发现的兴趣有所降低.然而,由于三方面的原因,这
The emergence of combinatorial chemistry has led to the discovery of new drugs that have been neglected for many years from natural products. Practice has proved that combinatorial chemistry as a tool for drug discovery needs to be further developed and perfected. The unique role of natural products in drug discovery has attracted renewed attention in recent years. Policymakers in the pharmaceutical industry must rethink natural product drug discovery strategies with new perspectives 1. Traditional natural product drug discovery has been neglected for years The rate of new drug production in the pharmaceutical industry has continued to decline in recent years and there are many factors contributing to this state of affairs, One reason for this may be the reduced interest in natural product drug discovery due to the introduction of new technologies, especially combinatorial chemistry, in the pharmaceutical industry, however, for three reasons