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Four novel 5-substituted pyridine-2(1H)-one derivatives were designed and synthesized by using addition-elimination reactions.The structures of these novelly synthesized compounds were verified by ~1H NMR,ESI-MS and single crystal X-ray diffraction.Furthermore,all four compounds(most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG2 2.2.15 cell,making them promising drug candidates for potential bioactive molecule against hepatitis B.
Four novel 5-substituted pyridine-2 (1H) -one derivatives were designed and synthesized by using addition-elimination reactions. The structures of these novelly synthesized compounds were verified by ~ 1H NMR, ESI-MS and single crystal X-ray diffraction. All four compounds (most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG2 2.2.15 cell, making them promising drug candidates for potential bioactive molecule against hepatitis B.