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1973年夏在美国的俄亥俄州的一家织物工厂工人中暴发了周围神经炎。大多数严重患者都在印染部门工作,他们把有色染料溶于挥发性溶剂中,涂于塑料的织物表面。数年来印染过程使用过含有90%甲基乙基酮(MEK)和10%甲基异丁基酮(MiBK)的混合溶剂。1972年夏季后甲基正丁基酮(MBK)逐渐代替了MiBK,1972年12月MBK使用量最大,不久发现了第一例周围神经炎,因此接触MBK很可能与神经炎暴发有关。但工厂环境调查发现神经炎发病率最高区域MEK的浓度比MBK的高,工人除空气接触外,还皮肤接触MEK和MBK,而且在工人的接触史中MEK的作用十分突出,这使作者怀疑MEK可能有
In the summer of 1973, peripheral neuritis broke out in a fabric factory worker in Ohio, United States. Most of the serious patients are working in the printing and dyeing department. They dissolve colored dyes in volatile solvents and apply them to the surface of plastic fabrics. For several years the printing process used a mixed solvent containing 90% methyl ethyl ketone (MEK) and 10% methyl isobutyl ketone (MiBK). Methyl n-butyl ketone (MBK) gradually replaced MiBK in the summer of 1972, MBK was used most in December 1972 and the first peripheral neuritis was soon discovered. Therefore, exposure to MBK is likely to be related to neuritis outbreaks. However, the factory environmental survey found that the MEK concentration in the area with the highest incidence of neuritis was higher than that in MBK. Workers exposed MEK and MBK to the skin in addition to air exposure, and the role of MEK in workers’ exposure history was prominent. This led the author to suspect MEK might have