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硝苯吡啶是心肌细胞和血管平滑肌细胞膜慢通道钙离子阻滞剂,对防治冠状动脉痉挛,扩张冠状动脉,治疗心绞痛有奇效。临床上对各种常规药物治疗无效的难治性心绞痛,用硝苯吡啶能收到显效;对高血压和心衰病人也有效。本药是目前较有效的抗心绞痛药物之一。因此有必要对它进一步深入了解和认识,以便合理恰当地用药。药理作用硝苯吡啶的药理学首先由Vater等于1972年作了详细描述。以后Fleckenstein等证明本药是心肌及血管平滑肌钙离子流入细胞的强抑制剂,从分子学水平研究发现,硝苯吡啶对钙离子流入细胞的抑制作用比别的药物都强。
Nifedipine is a slow-acting calcium channel blocker of cardiomyocytes and vascular smooth muscle cells, which has remarkable effects on the prevention and treatment of coronary artery spasm, coronary artery dilatation and angina pectoris. Clinically for various conventional drug treatment of refractory angina, nifedipine can receive markedly effective; for hypertension and heart failure patients are also effective. The drug is currently more effective anti-angina drugs. Therefore it is necessary to further understand and understand it in order to properly and properly medication. Pharmacological Pharmacology of nifedipine was first described in detail by Vater et al in 1972. After Fleckenstein and other evidence that the drug is a strong inhibitor of myocardial and vascular smooth muscle calcium ions into the cells, from the molecular level found that nifedipine calcium ion influx into cells than other drugs are stronger.