鱼藤酮预处理对于X射线诱导的HepG2细胞杀灭和生长抑制的放大作用(英文)

• 作 者: 张昕
• 出 处: IMP & HIRFL Annual Report
• 发表日期: 2010年00期
• 关键词: 鱼藤酮 X射线 mitochondrial intracellular mentioned oxidative 放大作用 radiotherapy center

Rotenone is a classical inhibitor of mitochondrial respiratory chain(MRC)which specifically inhibits electron transfer between iron-sulfur centers in MRC complex I and ubiquinone,which was previously reported would contribute to mitochondrial membrane potential(MMP)decrease,mitochondrial ROS production and intracellular oxidative stress,here we performed an in vitro experiment to test whether the effects mentioned above would pose any advantage for radiotherapy using X-ray.

Rotenone is a classical inhibitor of mitochondrial respiratory chain (MRC)which specifically inhibits electron transfer between iron-sulfur centers in MRC complex I and ubiquinone, which was previously reported would contribute to mitochondrial membrane potential(MMP)decrease,mitochondrial ROS production and intracellular oxidative Stress,here we performed an in vitro experiment to test whether the effects mentioned above would pose any advantage for radiotherapy using X-ray.