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目的观察前列腺E1联合低分子肝素辅助治疗老年冠心病心力衰竭的疗效及安全性。方法将同期收治的68例老年冠心病心力衰竭患者随机分为观察组和对照组各34例,均予扩张血管、利尿等常规抗心力衰竭治疗,观察组在此基础上静注前列腺素E1、皮下注射低分子肝素,均连续10d。观察两组心功能变化并判定疗效;治疗前后行心脏彩超检查,测定左室结构指标;观察不良反应发生情况。结果观察组和对照组总有效率分别为97.1%、79.4%(P<0.05),观察组左室结构指标改善情况优于对照组(P<0.05),两组均无严重不良反应发生。结论前列腺E1联合低分子肝素辅助治疗老年冠心病心力衰竭安全、有效。
Objective To observe the efficacy and safety of prostatic E1 combined with low molecular weight heparin in the treatment of elderly patients with coronary heart disease and heart failure. Methods Sixty-eight elderly patients with CHD who were treated at the same period were randomly divided into observation group and control group, 34 cases in each group. All patients were treated with routine anti-heart failure such as vasodilation and diuresis. On the basis of this observation, Subcutaneous injection of low molecular weight heparin, were continuous 10d. The changes of cardiac function were observed and the curative effect was observed. Before and after the treatment, cardiac color Doppler echocardiography was performed to determine the left ventricular structural parameters. The incidence of adverse reactions was observed. Results The total effective rate in observation group and control group was 97.1% and 79.4% respectively (P <0.05). The improvement of left ventricular structural parameters in observation group was better than that in control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Prostate E1 combined with low molecular weight heparin is safe and effective in the treatment of heart failure in elderly patients with coronary heart disease.