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本文报导四组实验大鼠(正常对照组,矽肺组、磷酸喹哌组、氮氧喹哌组)的血浆及肺冲洗中脂质过氧化物(Lipidperoxide简称LPO)的测定,结果发现,矽肺组血浆及肺冲洗液中LPO的光密度与正常对照组比较,差异非常显著,(P<0.01),提示矽肺的发生可能与游离基的生成有关。磷酸喹哌组和氮氧喹哌组血浆及肺冲洗液中LPO的光密度与矽肺组比较,差异非常显著P<0.01,提示作为抗矽肺药物磷酸喹哌及氮氧喹哌有降低LPO的作用。本实验结果为矽肺发病过程及治疗方面提供参考。
This article reports the determination of lipid and lipid peroxidation (LPO) in plasma and lungs in four groups of rats (normal control group, silicosis group, quipronol phosphate group and nifedipine group). It was found that in the silicosis group The optical density of LPO in plasma and lung irrigating fluid was significantly different from that in normal control group (P <0.01), suggesting that the occurrence of silicosis might be related to the formation of free radicals. Compared with the silicosis group, the optical density of LPO in the plasma and lung washings of the quinapir phosphate group and the nifedipine group was significantly lower than that of the silicosis group (P <0.01), suggesting that the anti-silicotic drugs quinpiripefonate and nitroquipron both had the effect of reducing LPO . The results of this experiment provide a reference for the pathogenesis and treatment of silicosis.