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目的探讨胃癌组织中周期素D1蛋白的表达在胃癌发生发展中的意义。方法应用免疫组织化学SP法,检测周期素D1在不同类型胃组织中的表达。结果周期素D1在胃癌、胃黏膜上皮中-重度不典型增生、轻度不典型增生、慢性浅表性胃炎和正常胃黏膜组织中的阳性表达率分别为64.41%、47.06%、32.73%、16.33%和5.08%。有病变的胃组织中的周期素D1蛋白表达均高于正常胃黏膜(P<0.05);胃癌组织周期素D1蛋白表达高于其他类型胃组织(P<0.05)。结论周期素D1过表达可能是胃癌发生过程中的早期分子事件。
Objective To investigate the expression of cyclin D1 in gastric carcinoma and its significance in the development of gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of cyclin D1 in different types of gastric tissues. Results The positive rates of cyclinD1 in gastric cancer, moderate-severe gastric dysplasia, mild dysplasia, chronic superficial gastritis and normal gastric mucosa were 64.41%, 47.06%, 32.73%, 16.33 % And 5.08%. The expression of cyclin D1 protein in diseased gastric tissues was higher than that in normal gastric mucosa (P <0.05). Cyclin D1 protein expression was higher in gastric cancer tissues than in other types of gastric tissues (P <0.05). Conclusion Overexpression of cyclin D1 may be an early molecular event in the development of gastric cancer.