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目的探讨瑞舒伐他汀对颈动脉粥样硬化患者血脂与颈动脉斑块的影响。方法将2015年10月—2016年10月进行治疗的54例颈动脉粥样硬化患者随机分为对照组和观察组各27例,对照组应用阿司匹林治疗,观察组在对照组基础上联合瑞舒伐他汀治疗,比较两组用药前后的血脂水平及颈动脉斑块情况,数据进行统计学处理,P<0.05为差异有统计学意义。结果观察组用药后甘油三酯、低密度脂蛋白、总胆固醇与高密度脂蛋白均优于对照组,比较差异均有统计学意义(均P<0.05);观察组用药后斑块个数(2.31±1.08)个、厚度(1.12±0.38)mm与硬化率(74.07%)均优于对照组的(2.58±1.16)个、(1.43±0.42)mm与40.74%,比较差异均有统计学意义(P<0.05)。结论颈动脉粥样硬化患者应用瑞舒伐他汀可有效改善血脂水平及斑块情况,值得推广应用。
Objective To investigate the effect of rosuvastatin on lipids and carotid plaque in patients with carotid atherosclerosis. Methods 54 cases of carotid atherosclerosis treated from October 2015 to October 2016 were randomly divided into control group and observation group, 27 cases in each group. The control group was treated with aspirin. The observation group was treated with Ruishu Statin treatment, compared the two groups before and after treatment of blood lipid levels and carotid plaque, the data were statistically analyzed, P <0.05 for the difference was statistically significant. Results The triglyceride, low density lipoprotein, total cholesterol and high density lipoprotein of the observation group were better than the control group after treatment, the difference was statistically significant (all P <0.05); the number of plaques 2.31 ± 1.08), thickness (1.12 ± 0.38) mm and sclerotic rate (74.07%) were significantly higher than those in control group (2.58 ± 1.16), (1.43 ± 0.42) mm and 40.74% respectively, with statistical significance (P <0.05). Conclusion The application of rosuvastatin in patients with carotid atherosclerosis can effectively improve the level of blood lipid and plaque, which is worth popularizing and applying.