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耐药伤寒的治疗已成为一个棘手的问题。在墨西哥和远东所发生的大规模流行,多半是由于携带耐多种药物(包括氯霉素、四圜素族、磺胺类和链霉素)R因子的伤寒菌株所引起的。有报告静脉使用大剂量氨苄青霉素(100～150mg/kg/天)治疗奏效。静脉使用氨苄青霉素花费大,且在伤寒呈地方性流行的发展中国家,静脉给药因花费大、医院设备不足而难于实行。故需寻找另一种可靠的口服药物来代替。有报告口服羟氨苄青霉素治疗奏效。但是,由于在墨西哥、印度、越南和泰国
The treatment of resistant typhoid fever has become a thorny issue. The pandemic that occurred in Mexico and the Far East was mostly caused by typhoid strains carrying R-factor resistant to a wide range of drugs, including chloramphenicol, tetracyacrine, sulfonamides and streptomycins. It has been reported that intravenous use of high-dose ampicillin (100 ~ 150mg / kg / day) treatment works. Intravenous ampicillin is costly, and in developing countries endemic to typhoid fever, intravenous administration is difficult to implement due to costly and inadequate hospital equipment. So need to find another reliable oral medication instead. There are reports of oral amoxicillin treatment works. However, due to Mexico, India, Vietnam and Thailand