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目的:观察术中局部化疗对大肠癌患者的预后影响,探讨提高大肠癌患者临床疗效的辅助治疗方法。方法:选择DuckB期和DuckC期患者76例,根据自愿的原则均分为常规手术组和术中化疗组,常规手术组采取常规手术治疗,术中化疗组在常规手术过程中给予局部化疗治疗,比较两组患者术后第7d血常规、肝肾功能及两组患者术后并发症,并随访两组患者术后12个月和24个月局部复发情况。结果:两组患者在术后血常规、肝肾功能及术后并发症方面比较,差异无统计学意义(P>0.05);术后12个月和24个月局部复发病例比较,差异具有统计学意义(P<0.05),术中化疗组显著少于常规手术组。结论:在DuckB期和DuckC期大肠癌患者外科手术治疗过程中,应积极采取术中化疗的治疗措施。
Objective: To observe the effect of intraoperative local chemotherapy on the prognosis of patients with colorectal cancer and explore the adjuvant therapy to improve the clinical efficacy of patients with colorectal cancer. Methods: Sixty-six patients with DuckB stage and DuckC stage were selected. According to the principle of voluntariness, they were divided into two groups: conventional operation group and intraoperative chemotherapy group. Conventional operation group received conventional operation. Intraoperative chemotherapy group received local chemotherapy during routine operation, The blood routine, liver and kidney function and postoperative complications of the two groups were compared on the 7th day after operation. The local recurrences at 12 months and 24 months after operation were compared between the two groups. Results: There was no significant difference in postoperative blood routine, liver and kidney function and postoperative complications between the two groups (P> 0.05). There was statistical difference between the two groups in the local recurrence at 12 months and 24 months Significance (P <0.05), intraoperative chemotherapy group was significantly less than the conventional surgery group. Conclusion: During the surgical treatment of patients with DuckB and DuckC colorectal cancer, intraoperative chemotherapy should be actively taken.