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目的观察转化生长因子β(TGF-β)、可溶性细胞黏附分子-1(sICAM-1)在慢性乙型肝炎患者中的水平变化,以及肝损害的不同程度与TGF-β、sICAM-1的关系。探讨TGF-β、sICAM-1对于肝病诊断的临床意义。方法对75例慢性乙型肝炎患者,采用ELISA法检测血清TGF-β、sICAM-1水平。结果75例慢性乙型肝炎患者血清TGF-β、sICAM-1水平均有不同程度的升高。慢性肝炎中度和重度者较正常对照组升高明显,差异显著(P<0.01)。慢性肝炎轻度与正常对照组相比无显著差异(P>0.05)。结论血清TGF-β、sICAM-1的水平变化,可作为反映肝组织炎症损害程度的较为灵敏的指标,对于判断慢性乙型肝炎病情变化,有一定的临床价值。
Objective To observe the changes of TGF-β, sICAM-1 in patients with chronic hepatitis B and the relationship between TGF-β, sICAM-1 and different degrees of liver damage . To investigate the clinical significance of TGF-β and sICAM-1 in the diagnosis of liver disease. Methods Serum levels of TGF-β and sICAM-1 in 75 patients with chronic hepatitis B were measured by ELISA. Results Serum levels of TGF-β and sICAM-1 in 75 patients with chronic hepatitis B were increased to some extent. Moderate and severe chronic hepatitis than normal control group increased significantly, the difference was significant (P <0.01). Chronic hepatitis mild compared with the normal control group was no significant difference (P> 0.05). Conclusion Serum levels of TGF-β and sICAM-1 may be used as a sensitive index to reflect the degree of inflammatory damage in liver tissue and have certain clinical value for judging the change of chronic hepatitis B.