苦葛蔓中的新三萜成分

• 作 者: 丁立生 窦永泽 张晓 彭树林 王明奎
• 机 构: 中国科学院成都生物研究所天然药物开放研究实验室
• 出 处: 药学学报
• 发表日期: 1999年02期
• 关键词: 苦葛蔓 云南葛藤 三萜 3β 15α 23-三羟基齐墩果-12-烯-16-酮 3β 15α-二羟基齐墩果-12-烯-16-酮

目的：对苦葛蔓（ＰｕｅｒａｒｉａｐｅｄｕｎｃｕｌａｒｉｓＧｒａｈ．）酸水解产物中的化学成分进行分离和结构鉴定。方法：用各种色谱技术进行分离，得到３个五环三萜化合物，用ＭＳ，１ＨＮＭＲ，１３ＣＮＭＲ（ＤＥＰＴ），ＨＭＱＣ，ＨＭＢＣ和ＮＯＥＳＹ谱鉴定化合物。结果：经光谱鉴定化合物１为３β，１５α，２３三羟基齐墩果１２烯１６酮，化合物２为３β，１５α二羟基齐墩果１２烯１６酮，化合物３为３β，２２β，２４三羟基齐墩果１２烯（ｓｏｙａｓａｐｏｇｅｎｏｌＢ）。结论：化合物１和化合物２为新化合物。

Objective: To isolate and identify the chemical constituents from acid hydrolysis products of Pueraria peduncularis Grah. Methods: The compounds were separated by various chromatographic techniques. Three pentacyclic triterpene compounds were obtained. The compounds were identified by MS, 1H NMR, 13C NMR (DEPT), HMQC, HMBC and NOESY spectra. RESULTS: Compound 1 was identified as 3β,15α,23trihydroxy-alkanol12ene16ketone by spectrum, compound 2 was 3β, 15αdihydroxy arsonol12en-16ketone, and compound 3 is 3β, 22β, 24trihydroxy oleo12ene (soyasapogenol B). Conclusion: Compound 1 and Compound 2 are new compounds.