IgA肾病患者血清中的抗核抗体

• 作 者: 徐伟人
• 出 处: 国外医学(内科学分册)
• 发表日期: 1991年08期
• 关键词: 抗核抗体 IgA肾病 肾小球肾病 自身免疫现象 自身免疫因素 自身免疫疾病 肾小球肾炎 高分子量 类风湿因子 强直性脊柱炎

IgA 肾病(IgAN)是最常见的肾小球肾炎,有关其发病机理迄今仍不清楚。在众多的病因中,自身免疫因素尚不能排除。IgAN 常伴自身免疫疾病和自身免疫现象,如血小板减少症、强直性脊柱炎、冷反应性抗核抗体和高分子量的循环 IgA 型类风湿因子。本文旨在测定 IgAN 患者血清中五种抗核抗体滴度增高的发生率,并同正常对照组及其它原发性肾小球肾病进行比较。

IgA nephropathy (IgAN) is the most common glomerulonephritis, the pathogenesis of which remains unclear so far. In many causes, autoimmune factors can not be ruled out. IgAN is often accompanied by autoimmune and autoimmune phenomena such as thrombocytopenia, ankylosing spondylitis, cold-reactive antinuclear antibodies, and circulating high-molecular-weight IgA-type rheumatoid factor. The purpose of this article is to determine the prevalence of elevated titers of five antinuclear antibodies in serum of IgAN patients and to compare them with normal controls and other primary glomerular nephropathy.