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1 血吸虫病肝纤维化研究进展值得借鉴 1904年英国病理学家西蒙对血吸虫病患者的肝脏病理改变作了全面描述,称之为“西蒙氏肝纤维化”(Symmer’s fibrosis)。至今亦认为单纯日本血吸虫病肝脏的病理是纤维组织大量增生、胶原沉积造成纤维阻塞性肝损伤,而无假小叶及再生结节,此有别于肝硬变。1984年Wu等在美国肝病年会上报道用分子杂交技术检测血吸虫病肝纤维化动物肝脏Ⅰ型胶原mRNA,这表明其研究已进入分子生物学水平。在我国,致肝纤维化主
1 schistosomiasis liver fibrosis research is worth drawing on 1904 British pathologist Simon in schistosomiasis patients with liver pathological changes were fully described, called “Symmer’s fibrosis” (Symmer’s fibrosis). Up to now it is also considered that the pathology of liver in pure schistosomiasis japonica is hyperplasia of fibrous tissue, which causes fibrous obstructive liver injury without pseudolobule and regenerative nodules, which is different from cirrhosis. In 1984, Wu et al reported at the annual meeting of Liver Diseases in the United States of molecular hybridization detection of liver fibrosis in animals with type Ⅰ collagen mRNA of schistosomiasis, indicating that the study has entered the molecular biology level. In our country, leading to liver fibrosis