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【目的】探讨甲泼尼龙联合干扰素治疗毛细支气管炎的疗效分析,为临床诊治提供参考依据。【方法】将182例患儿随机分为治疗组和对照组各91例,对照组均给予改善通气、抗感染、止咳化痰等常规综合治疗;治疗组在对照组的基础上,给予静脉滴注甲泼尼龙1～2mg/kg,2～3次/d,连用3d、3d后开始减量,并雾化吸入干扰素α-1b,1.0μg/kg,1次/d,疗程均3～5d;观察两组治疗前后咳嗽、喘憋、肺部体征等变化。【结果】治疗组和对照组总有效率分别为97.6%、82.4%,两组比较差异有统计学意义(P<0.01);治疗组在咳嗽、喘憋和肺部喘湿鸣音消失、平均住院时间等方面均优于对照组,两组比较差异有统计学意义(P<0.01)。【结论】甲泼尼龙联合干扰素治疗毛细支气管炎疗效安全,能有效地缩短治愈时间。
【Objective】 To investigate the efficacy of methylprednisolone combined with interferon in the treatment of bronchiolitis and provide a reference for clinical diagnosis and treatment. 【Methods】 One hundred and eighty-two children were randomly divided into treatment group and control group, with 91 cases in each group. The control group was given routine treatment such as ventilation, anti-infection and cough-resolving phlegm. On the basis of the control group, Injection methylprednisolone 1 ~ 2mg / kg, 2 ~ 3 times / d, even 3d, 3d after reduction, and inhalation of interferon α-1b, 1.0μg / kg, 5d; observe the two groups before and after treatment cough, wheezing, lung signs and other changes. 【Results】 The total effective rates of the treatment group and the control group were 97.6% and 82.4%, respectively, with significant difference between the two groups (P <0.01). In the treatment group, the total effective rate of cough, wheezing, Hospital stay, etc. were better than the control group, the difference between the two groups was statistically significant (P <0.01). 【Conclusion】 Methylprednisolone combined with interferon in the treatment of bronchiolitis is safe and can shorten the cure time effectively.