论文部分内容阅读
研究结果表明,当雌性小鼠接触CS_2浓度达到97mg/m~3 时,染毒31天(约小鼠的6个动情周期)后,与正常雄性小鼠交配,染毒小鼠受孕率下降,仔代(F_1代)4日存活率、7日存活率及哺育存活率均下降,但与对照组比较无显著差异。F_1代雌性仔鼠性器官发育延迟,且行为发育亦有明显改变。F_1代仔鼠受孕率(25.0％)较对照组(70.0％)明显降低(P<0.01),F_2代仔鼠活胎率(87.5％)显著低于对照组(96.8％,P<0.05),认为CS_2的性腺毒性具有远期效应。
The results showed that when the female mice were exposed to CS 2 at a concentration of 97 mg / m 3, the female mice were mated with normal males after 31 days of exposure (about 6 estrous cycles of mice), the conception rate of the mice was decreased, On the 4th generation, the F_1 generation survived on the 4th, the surviving on the seventh and surviving on the seventh day decreased, but no significant difference compared with the control group. F_1 female offspring sexual organ development delay, and behavioral development has also been significantly changed. The pregnancy rate of F_1 offspring mice was significantly lower than that of the control group (70.0% vs. 25.0%, P <0.01), while the F 2 offspring survival rate (87.5%) was significantly lower than that of the control group (96.8%, P <0.05) It is thought that gonadal toxicity of CS_2 has a long-term effect.