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目的探讨双水平无创正压通气治疗慢性阻塞性肺疾病(COPD)并发Ⅱ型呼吸衰竭患者的临床疗效。方法 2008年7月～2011年4月期间,我科共收治COPD并发Ⅱ型呼吸衰竭患者153例,我们将前述患者随机分成2组,其中观察组76例,接受常规治疗联合双水平无创正压通气治疗;对照组77例,接受单纯性常规常规治疗。比较两组患者治疗前后的血气分析结果。结果两组患者治疗前pH、氧分压(PaO2)、二氧化碳分压(PaCO2)、氧饱和度(Sa02)差异无统计学意义(P均﹥0.05)。治疗后,观察组的pH、PaO2、Sa02显著高于对照组,PaCO2显著低于对照组,两者相比差异有统计学意义(P均﹤0.05)。结论双水平无创正压通气治疗COPD并发Ⅱ型呼吸衰竭患者的疗效良好,该治疗方法值得临床推广与应用。
Objective To investigate the clinical effect of double-level non-invasive positive pressure ventilation in treating patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods From July 2008 to April 2011, 153 cases of COPD complicated with type Ⅱ respiratory failure were treated in our department. We randomly divided the above patients into two groups, of which 76 cases in the observation group received conventional therapy combined with bi-level noninvasive positive pressure Ventilation treatment; control group of 77 patients received simple routine conventional treatment. Blood gas analysis results before and after treatment were compared between the two groups. Results There was no significant difference in pH, PaO2, PaCO2 and SaO2 before treatment in both groups (all P> 0.05). After treatment, the pH, PaO2 and SaO2 in the observation group were significantly higher than those in the control group, PaCO2 was significantly lower than the control group, the difference was statistically significant (P all <0.05). Conclusion The double-level non-invasive positive pressure ventilation in patients with COPD complicated by type Ⅱ respiratory failure has a good curative effect. The treatment is worthy of clinical application and promotion.