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为了探讨血清碱性磷酸酶(ALP)在肿瘤骨转移诊断中的意义,测定365例恶性肿瘤患者(未出现骨转移)、176例肿瘤骨转移患者和246名健康成人的血清ALP活性。恶性肿瘤组血清ALP活性高于健康对照组,t=8.770,P<0.01;肿瘤骨转移组血清ALP活性高于前两者,t值分别为10.490和13.883,P值均<0.01。接受手术治疗的恶性肿瘤患者术前血清ALP活性与健康对照组差异无统计学意义,出现骨转移后则明显升高。初步研究结果提示,血清ALP活性与肿瘤骨转移有一定的相关性。定期检测恶性肿瘤患者的血清ALP活性,可以作为判断肿瘤骨转移的一个重要参考指标。
To investigate the significance of serum alkaline phosphatase (ALP) in the diagnosis of bone metastases, serum ALP activity was measured in 365 patients with malignant tumor (without bone metastasis), 176 patients with tumor metastasis and 246 healthy adults. The serum ALP activity of malignant tumor group was higher than that of healthy control group (t = 8.770, P <0.01). The serum ALP activity of tumor metastasis group was higher than the former two groups (t = 10.490 and 13.883, P <0.01). Preoperative serum ALP activity in patients with malignant tumors undergoing surgery was not significantly different from that in healthy controls, but was significantly increased after bone metastases. Preliminary results suggest that serum ALP activity and tumor bone metastasis have a certain correlation. Regular detection of serum ALP activity in patients with malignant tumors can be used as an important reference to determine the bone metastasis of the tumor.