论文部分内容阅读
目的：观察难治性高血压患者采用螺内酯治疗的临床效果。方法：选择难治性高血压患者82例作为研究对象，该组患者经包含利尿剂在内的三种及以上降压药治疗8周以上血压仍不能控制者（对照组）；对照组患者转为研究组，治疗方案为血管紧张素转换酶抑制剂/血管紧张素受体拮抗剂＋钙离子拮抗剂＋利尿剂+螺内酯，对两组患者的血压变化、电解质、肾功能、动脉弹性、心脏超声功能及药物的安全性进行对比及观察分析。结果：研究组患者在血压改善上要明显优于对照组；动脉脉搏波传导速（P W V）值明显减小；LVEDD、LVESD、LVEF、FS均有明显好转，有显著性差异（P＜0.05）；未见明显不良反应。结论：对于难治性高血压患者，加用螺内酯可以明显控制患者血压，改善心脏和血管的功能，值得临床借鉴。“,”Objective To observe patients with refractory hypertension clinical effects of spironolactone therapy. Methods 82 patients with refractory hypertension as research subjects, this group included patients with diuretics, including three or more antihypertensive drug therapy is still not more than eight weeks of blood pressure control (control group);control group of patients transferred for the study group, the treatment options for angiotensin-converting enzyme inhibitors/angiotensin receptor blockers+diuretics, calcium antagonists++spironolactone, two groups of patients for changes in blood pressure, electrolytes, renal function, arterial elasticity, heart comparison and analysis of observed and drug safety functions performed ultrasound. Results The study group on the blood pressure of patients improve significantly better than the control group;arterial pulse wave velocity (PWV) value is significantly reduced;LVEDD, LVESD, LVEF, FS were significantly improved, there was a significant difference (P<0.05);no significant adverse reactions. Conclusion For patients with refractory hypertension, the addition of spironolactone can significantly control the blood pressure, improve the function of the heart and blood vessels, is worthy of reference.