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The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface for cell culture, it can be used to detect bioelectrical parameters of cells.The characteristic curve for photocurrent versus applied bias voltage to the system shows a current-voltage curve (Ⅰ-Ⅴcurve).This technique can be used to detect the action potential changes towards different drugs based on the bias voltage dependence of an optical current,and provides a dynamic system by scanning light beam at the very cell on the sensor device.The LAPS overcomes the limitation of recording sites,but high spatial resolution and sensitivity are also paramount.This paper discussed a novel structure of LAPS array for extracellular monitoring to decrease potential noise level.Both characteristics of active recording array areas and cell culture conditions are measured.
The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) structure.By depositing biocompatible layers on the sensing surface for cell culture, it can be used to detect bioelectrical parameters of cells The characteristic curve for photocurrent versus applied bias voltage to the system shows a current-voltage curve (I-Vcurve). This technique can be used to detect the action potential changes towards different drugs based on the bias voltage dependence of an optical current, and provides a dynamic system by scanning light beam at the very cell on the sensor device. LAPS overcomes the limitation of recording sites, but high spatial resolution and sensitivity are also paramount. This paper discussed a novel structure of LAPS array for extracellular monitoring to decrease potential noise level. Characteristics of active recording array areas and cell culture conditions are measured.