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目的探讨hs-CRP、Um-Alb与冠状动脉病变严重程度之间的相关性,以确定两者能否作为冠状动脉病变严重程度的一项预测性指标。方法以312例经冠状动脉造影确诊的冠心病组与145例对照组为研究对象,按冠状动脉病变严重程度和病变支数进行临床分组,比较不同组间hs-CRP、Um-Alb的差异。结果冠状动脉病变支数SVD、DVD、MVD各组之间比较,hs-CRP差异无统计学意义(P>0.05),Um-Alb随冠状动脉病变支数的增加而逐步升高,差异有统计学意义(P<0.05);冠心病不同严重程度组别间,hs-CRP、Um-Alb均显著高于对照组,差异有统计学意义(P<0.05);SAP、UAP、AMI各组之间比较,hs-CRP、Um-Alb均与冠心病的严重程度成正相关,随着冠心病的严重程度增加而逐步增高,差异有统计学意义(P<0.05)。结论 hs-CRP、Um-Alb与冠状动脉病变严重程度成正相关,两项目联合检测有助于冠状动脉病变范围和严重程度的判断。
Objective To investigate the correlation between hs-CRP, Um-Alb and the severity of coronary artery disease in order to determine whether they can be used as a predictor of the severity of coronary artery disease. Methods Three hundred and thirteen CHD patients with coronary artery disease confirmed by coronary angiography and 145 control subjects were enrolled in this study. According to the severity of coronary artery lesion and the number of lesions, the differences of hs-CRP and Um-Alb between different groups were compared. Results There was no significant difference in hs-CRP between the groups of coronary artery lesions (SVD, DVD, MVD) (P> 0.05). Um-Alb gradually increased with the increase of coronary lesions (P <0.05). The levels of hs-CRP and Um-Alb in different severity groups of coronary heart disease were significantly higher than those in control group (P <0.05) Between the two groups, hs-CRP and Um-Alb were positively correlated with the severity of coronary heart disease and gradually increased with the severity of coronary heart disease (P <0.05). Conclusion The hs-CRP and Um-Alb are positively correlated with the severity of coronary artery disease. The combination of two items can be helpful to judge the extent and severity of coronary artery disease.