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为观察镓盐对维甲酸致大鼠骨质疏松动物模型血中碱性磷酸酶 (AL P)和抗酒石酸酸性磷酸酶 (TRAP)水平及其变化趋势 ,选用 3月龄 SD雌性大鼠 45只 ,随机分为两组 :正常组 (13只 )和骨质疏松组 (32只 ) ,骨质疏松组按 85 mg/ kg· d维甲酸灌胃 15天 ,然后进入治疗阶段。实验分为四组 :正常组 (6只 ) ,骨质疏松组 (6只 ) ,正常喂养 ;氯化镓治疗组 (9只 ) ,2 5 mg/ kg·d氯化镓灌胃 ;雌激素治疗组 (6只 ) ,雌激素 0 .2 μg/ kg,3次 /周 ,腹腔注射 ,治疗两个月。结果显示模型期骨质疏松组 AL P和 TRAP显著升高 ,镓盐治疗后 AL P和 TRAP降低 ,与正常组接近 ,提示镓盐能抑制破骨细胞活性 ,降低骨转化率。
In order to observe the changes of ALP and TRAP in gallbladder rats induced by retinoic acid and the changes of the levels of ALP and TRAP, 45 female SD rats Were randomly divided into two groups: the normal group (13) and the osteoporosis group (32). The osteoporosis group was treated with 85 mg / kg · d-tretinoin for 15 days and then entered the treatment phase. The experiment was divided into four groups: normal group (6), osteoporosis group (6), normal feeding; gallium chloride treatment group (9), 25 mg / kg · d gallium chloride gavage; estrogen The treatment group (6), estrogen 0.2 g / kg, 3 times / week, intraperitoneal injection for two months. The results showed that ALP and TRAP were significantly increased in osteoporosis group during model period, ALP and TRAP decreased after gallium salt treatment, which was close to normal group, suggesting that gallium salt can inhibit osteoclast activity and decrease bone turnover rate.