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目的探讨母血清α1微球蛋白(AIM)、胎儿血红蛋白(Hb F)在妊娠早中期对于子痫前期的预测价值。方法选取在医院建卡产检的单胎初产妇346例,妊娠12~15+6周,知情同意留取血液学标本;采用动态散射比浊法检测α1微球蛋白浓度、毛细管电泳法检测胎儿血红蛋白的比例,并评估两者对早期预测子痫前期的临床意义。结果轻度子痫前期38例,重度子痫前期29例,妊娠期高血压40例,正常妊娠孕妇239例。子痫前期患者AIM、Hb F%水平均高于正常孕妇组,差异有统计学意义(P<0.05);重度子痫前期患者AIM、Hb F%水平高于轻度子痫前期组,差异有统计学意义(P<0.05)。结论 AIM、Hb F%对于早期预测子痫前期的敏感度、特异性均较高,并对疾病的发展及预后评估有一定价值,可联合作为早期诊断子痫前期的指标。
Objective To investigate the predictive value of maternal serum α1-microglobulin (AIM) and fetal hemoglobin (Hb F) in pre-eclampsia. Methods 346 cases of singleton primiparous women who underwent card check-up in hospital were enrolled in this study. Blood samples were collected with informed consent from 12 to 15 + 6 weeks of gestation. Α1 microglobulin concentration was measured by dynamic nephelometry and fetal hemoglobin And to assess the clinical significance of the two in predicting preeclampsia. Results There were 38 cases of mild preeclampsia, 29 cases of severe preeclampsia, 40 cases of gestational hypertension and 239 cases of normal pregnant women. The levels of AIM and Hb F% in patients with preeclampsia were significantly higher than those in normal pregnant women (P <0.05). The levels of AIM and Hb F% in patients with severe preeclampsia were higher than those in patients with mild preeclampsia Statistical significance (P <0.05). Conclusions The sensitivity and specificity of AIM and Hb F% for early prediction of preeclampsia are high, and have certain value for disease development and prognosis evaluation, which can be combined as an indicator of early diagnosis of preeclampsia.