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胰腺导管内乳头状黏液肿瘤(IPMN)是一种较少见的胰腺囊性肿瘤,具有恶变为胰腺导管腺癌的风险,且一旦发生恶变,预后较差。目前国内外针对IPMN的研究较少,因此,更好地理解其发生发展的分子病理学机制对于该疾病的诊断、治疗和预后改善具有重要意义。已发现多种癌基因、抑癌基因、信号通路等分子参与了IPMN的发生发展及恶变过程,笔者着重对IPMN的分子病理学研究进展进行综述。
Pancreatic ductal papillary mucinous neoplasm (IPMN) is a rare pancreatic cystic tumor with a risk of malignant transformation to pancreatic ductal adenocarcinoma, and has a poor prognosis in the event of malignant transformation. At present, there are few researches on IPMN both at home and abroad. Therefore, it is of great significance to understand the molecular pathology mechanism of its occurrence and development better for the diagnosis, treatment and prognosis of this disease. A variety of oncogenes, tumor suppressor genes and signaling pathways have been found to be involved in the occurrence, development and malignant transformation of IPMN. The author reviews the molecular pathology of IPMN.