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目的:探讨云南汉族人群中microRNAs(miRNAs)基因多态性与HCV慢性感染的相关性。方法:选取云南汉族人群HCV慢性感染者384例,健康对照人群379例,采用Taq Man探针基因分型方法对4个miRNAs的SNPs(miR196a2中的rs11614913、miR146a中的rs2910164、miR26a1中的rs7372209以及miR124a中的rs531564)进行基因分型,比较这4个SNPs位点基因型和等位基因频率在病例组和对照组中的分布,分析这4个SNPs与HCV慢性感染的相关性。结果 :rs11614913(C>T)、rs2910164(C>G)、rs7372209(T>C)、rs531564(C>G)4个SNPs位点的基因型频率和等位基因频率在病例组与对照组中的分布差异无统计学意义(P>0.05)。结论:miR196a2中的rs11614913、miR146a中的rs2910164、miR26a1中的rs7372209以及miR124中的rs531564与云南汉族人群HCV慢性感染无相关性。
Objective: To investigate the association between microRNAs (miRNAs) gene polymorphism and chronic hepatitis C in Yunnan Han population. Methods: A total of 384 HCV chronic hepatitis B patients and 379 healthy control subjects were enrolled in this study. TaqMan probe genotyping was used to analyze the SNPs of four miRNAs (rs11614913 in miR196a2, rs2910164 in miR146a, rs7372209 in miR26a1 and rs531564 in miR124a) were genotyped. The genotypes and allele frequencies of these 4 SNPs were compared among case group and control group. The correlation between the 4 SNPs and chronic HCV infection was analyzed. Results: The frequencies of genotypes and alleles of rs11614913 (C> T), rs2910164 (C> G), rs7372209 (T> C) and rs531564 (C> G) There was no significant difference in the distribution (P> 0.05). CONCLUSIONS: rs11614913 in miR196a2, rs2910164 in miR146a, rs7372209 in miR26a1, and rs531564 in miR124 have no correlation with HCV chronic infection in Yunnan Han population.