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固有免疫反应是机体抵御病原微生物的第一道防线。机体感染病原微生物后,有许多基因的转录和表达异常与过度炎症导致的组织损伤相关。来自美国西奈山伊坎医学院的Marazzi研究团队在对DNA拓扑异构酶Ⅰ(DNA topoisomeraseⅠ,TopⅠ)的研究中发现,TopⅠ能够在病原微生物感染后特异地上调RNA聚合酶Ⅱ的转录活性,从而引起过度炎症反应和组织损伤。该研究通过筛选9种靶向染色质结构的化学抑制剂,在流感和SEV病毒感染模型中发现FVD、JQ-1和CPT这三种抑制剂
The innate immune response is the body’s first line of defense against pathogenic microorganisms. After the body is infected with pathogenic microorganisms, many genes are abnormally transcribed and expressed that are associated with tissue damage caused by excessive inflammation. In a study of DNA topoisomerase Ⅰ (Top Ⅰ), a Marazzi team from Icahn Medical School in Mount Sinai, USA, found that Top Ⅰ specifically up-regulates the transcriptional activity of RNA polymerase Ⅱ after infection with pathogenic microorganisms Cause excessive inflammation and tissue damage. In this study, by screening nine chemical inhibitors targeting chromatin structure, three inhibitors of FVD, JQ-1 and CPT were found in influenza and SEV viral infection models