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目的:探讨特异性免疫治疗对哮喘儿童生命质量及肺功能的影响。方法:将我院哮喘中心建档管理的哮喘儿童根据治疗情况分为两组,研究组(26例)在常规《全球哮喘防治创议》(GINA)治疗方案的基础上进行特异性免疫治疗(SIT);对照组(16例)按照常规GINA方案治疗。入组及治疗满1年时由家长填写儿童生命质量量表体系(Peds QLTM)3.0哮喘模块中文版,比较两组入组时和治疗满1年后生命质量得分及肺功能检测的结果。结果:治疗1年后,研究组Peds QL症状分、治疗分、沟通分及总分均有所增加(P<0.05),忧虑分虽增加,但差异无统计学意义(P>0.05)。对照组Peds QL各维度和总分变化差异均无统计学意义(P>0.05)。两组入组时和治疗1年后的肺功能指标比较,差异均无统计学意义。结论:SIT比传统的激素吸入治疗更能提高患儿的生命质量(QOL)症状分、治疗分、沟通分和总分,两种治疗方法对QOL忧虑分和肺功能指标影响的差异尚未发现有统计学意义。应综合考虑包括患儿生命质量在内的实际情况选择治疗方式。
Objective: To investigate the effect of specific immunotherapy on the quality of life and lung function in children with asthma. Methods: The asthma children under the management of the asthma center in our hospital were divided into two groups according to the treatment. The study group (26 cases) was given specific immunotherapy based on the conventional GINA treatment plan (SIT ); Control group (16 cases) according to conventional GINA regimen. At the end of enrollment and treatment, the Peds QLTM 3.0 Chinese version of the Asthma Module 3.0 was completed by the parents at one year after enrollment. The quality of life scores and lung function tests were compared between the two groups at enrollment and after one year of treatment. Results: After 1 year of treatment, the scores of symptom, treatment, communication and total score of Peds QL in study group increased (P <0.05), while the anxiety score increased, but the difference was not statistically significant (P> 0.05). There was no significant difference in all dimensions and total score of Peds QL in control group (P> 0.05). There were no significant differences in the indexes of pulmonary function between the two groups when they were treated and after one year of treatment. CONCLUSIONS: Compared with traditional hormone inhalation therapy, SIT can improve the quality of life (QOL) symptom score, treatment score, communication score and total score in children. There is no difference between the two treatment methods on QOL anxiety score and pulmonary function index Statistical significance. Should be considered, including the quality of life of children, including the actual situation of choice of treatment.