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目的 :研制复合bBMP的异种骨庆大霉素局部药物释放系统 ,为治疗开放性骨折提供简便有效方法。材料和方法 :以复合bBMP的异种骨为核心载体 ,采用明胶包裹法和聚已内酯 (Poly ε caprolacton ,PCL)多重包裹法制成复合庆大霉素的植骨材料 ,对其进行表面结构和体外释放实验研究。结果 :2种方法制成的植骨材料均在 2 4h内有一爆发释放 ,并能维持一定时间的缓慢释放。其中PCL多重包裹法制成的RBX -G -LDDS在 2 5d时仍能达到 4.38ug/ml的释放浓度 ,高于庆大霉素对金黄色葡萄球菌的MIC(2ug/ml)。结论 :RBX -G -DDS具有良好的体外缓释特性 ,结合RBX的诱导成骨作用 ,能提供一种治疗开放性骨折的新方法
OBJECTIVE: To develop a multi-bBMP xanthogenic gentamicin local drug delivery system that provides a simple and effective method for the treatment of open fractures. MATERIAL AND METHODS: The composite bBMP xenografted bone was used as the core carrier. Gelatin-coated poly (caprolactone) and polycaprolactone (PCL) Experimental study on in vitro release. Results: The bone graft materials prepared by the two methods all had an explosive release within 24 hours and maintained a slow release for a certain period of time. Among them, RBX-G-LDDS made by PCL multi-package method still reached the release concentration of 4.38ug / ml at 25 days, which was higher than the MIC of gentamicin to Staphylococcus aureus (2ug / ml). CONCLUSION: RBX-G-DDS has good sustained-release characteristics in vitro. Combined with RBX-induced osteogenesis, RBX-G-DDS can provide a new method for the treatment of open fractures