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目的:探讨内镜下注射聚桂醇与组织胶治疗肝硬化食管胃底静脉曲张的疗效。方法:选择我院于2014年2月~2015年12月间收治的肝硬化食管胃底静脉曲张患者共88例,经随机数字表法将患者分为观察组及对照组各44例。给予观察组内镜下注射聚桂醇与组织胶治疗,给予对照组内镜下注射碘化油与组织胶治疗。统计两组患者手术中组织胶总用量,注射点数及平均每点组织胶用量。治疗14d后行胃镜检查,评价两组患者疗效,统计两组患者再出血、再出血死亡情况与不良反应情况。结果:观察组组织胶总用量、平均每点组织胶用量均低于对照组,差异均有统计学意义(P<0.05);治疗6个月后观察组疗效总有效率高于对照组,差异均有统计学意义(P<0.05)。两组注射点数、再出血发生率、再出血死亡率及并发症发生率比较无统计学差异(P>0.05)。结论:经内镜下注射聚桂醇与组织胶治疗肝硬化食管胃底静脉曲张安全有效,治疗费用低,值得推广。
Objective: To investigate the efficacy of endoscopic injection of lauromacyl alcohol and tissue glue in the treatment of patients with esophageal and gastric varices. Methods: A total of 88 patients with esophageal and gastric varices were enrolled in our hospital from February 2014 to December 2015. The patients were divided into observation group and control group by random number table. The observation group was given endoscopic injection of lauryl alcohol and tissue glue, and the control group was treated with endoscopic injection of iodized oil and tissue glue. The total amount of tissue glue, the number of injection points and the average amount of glue for each point of the operation in the two groups were calculated. Gastroscopy was performed 14 days after treatment to evaluate the curative effect of the two groups of patients. Statistics were made on the rebleeding, rebleeding and adverse reactions of the two groups. Results: The total amount of tissue glue in the observation group was lower than that in the control group (P <0.05). The total effective rate of the observation group after 6 months of treatment was higher than that of the control group All were statistically significant (P <0.05). There was no significant difference in the number of injection points, the rate of rebleeding, the rate of rebleeding and the incidence of complications between the two groups (P> 0.05). Conclusion: It is safe and effective to treat laparoscopic esophageal and gastric varices by endoscopic injection of lauromacyl alcohol and tissue glue, which is worth to be popularized.