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[目的]研究肝硬化死亡患者营养相关指标。[方法]对50例肝硬化死亡患者临终前营养相关生化指标进行回顾性分析,依据凝血酶原活动度(PTA)水平分组,PTA>40%(未合并肝功能衰竭)为A组,PTA≤40%(合并肝功能衰竭)为B组,采用统计学方法对2组资料进行计量资料的t检验。[结果]A组:MELD(12.76±6.25)分、PTA(59.66±15.87)%、总胆红素(53.28±63.68)μmol/L、直接胆红素(32.66±38.70)μmol/L、白蛋白(22.87±3.84)g/L、前白蛋白(70.63±25.01)mg/L、淋巴细胞计数(0.87±0.38)×109/L;B组:MELD(27.89±9.88)分、PTA(22.71±8.20)%、总胆红素(260.25±186.36)μmol/L、直接胆红素(167.49±136.30)μmol/L、白蛋白(23.17±4.18)g/L、前白蛋白(49.39±39.87)mg/L、淋巴细胞计数(1.75±3.44)×109/L。2组MELD评分、总胆红素、直接胆红素比较差异有统计学意义(P<0.05),2组营养学指标白蛋白、前白蛋白指标及淋巴细胞计数比较均差异无统计学意义(P>0.05)。[结论]所有肝硬化死亡的患者无论PTA%大小,均存在严重白蛋白、前白蛋白、总淋巴细胞计计数下降等营养不良状况。
[Objective] To study the nutrition-related indexes of patients died of cirrhosis. [Methods] A retrospective analysis was performed on the biochemical indicators of pre-natal nutrition in 50 patients with death from cirrhosis. According to the level of prothrombin activity (PTA), PTA> 40% (without hepatic failure) 40% (with liver failure) for the B group, the two groups of data using statistical methods t test. [Results] In group A, the serum levels of MELD (12.76 ± 6.25), PTA (59.66 ± 15.87)%, total bilirubin (53.28 ± 63.68) μmol / L and direct bilirubin (32.66 ± 38.70) μmol / (22.87 ± 3.84) g / L, Pre-albumin (70.63 ± 25.01) mg / L and Lymphocyte count (0.87 ± 0.38) × 109 / L respectively.The patients in group B had a MELD of 27.89 ± 9.88 and a PTA of 22.71 ± 8.20 ), Total bilirubin (260.25 ± 186.36) μmol / L, direct bilirubin (167.49 ± 136.30) μmol / L, albumin (23.17 ± 4.18) g / L and prealbumin (49.39 ± 39.87) mg / L, lymphocyte count (1.75 ± 3.44) × 109 / L. There were significant differences in MELD score, total bilirubin and direct bilirubin between the two groups (P <0.05). There was no significant difference in nutritional index albumin, prealbumin index and lymphocyte count between the two groups P> 0.05). [Conclusion] All patients with cirrhosis died of malnutrition, including severe albumin, prealbumin and total lymphocyte count, no matter the size of PTA%.