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目的了解宫颈病变患者配偶人乳头瘤病毒(HPV)感染情况,为宫颈病变的预防提供依据。方法对2009年12月至2011年4月在深圳市人民医院妇科门诊就诊,有宫颈病变且高危型HPV检测阳性的患者共86例及健康妇女35例(其配偶分别为研究组86例和对照组35例),采用PCR体外扩增和DNA反向点杂交相结合的DNA芯片技术,检测其配偶阴部HPV感染情况。结果研究组HPV检出阳性率为45.35%(39/86),明显高于正常对照组的17.14%(6/35)(P﹤0.01)。研究组HPV阳性者中有53.8%(21/39)的夫妻双方感染相同的HPV亚型,其中52型占首位。结论宫颈病变患者配偶HPV感染明显高于正常人群,且部分夫妻感染相同的HPV亚型,故对配偶进行HPV检测和健康宣教有利于宫颈病变的预防。
Objective To understand the status of spouse human papillomavirus (HPV) infection in patients with cervical lesions and provide the basis for the prevention of cervical lesions. Methods From December 2009 to April 2011, 86 cases of cervical lesions and high-risk HPV tests were positive in gynecological clinic of Shenzhen People’s Hospital, and 35 healthy women (their spouses were 86 cases and control group respectively 35 cases). HPV DNA was detected by polymerase chain reaction in vitro amplification and DNA reverse dot blot hybridization. Results The positive rate of HPV in study group was 45.35% (39/86), which was significantly higher than that in normal control group (17.14%, 6/35) (P <0.01). In the study group, 53.8% (21/39) of the HPV-positive patients were infected with the same HPV subtypes, of which 52 accounted for the top. Conclusion The spouse HPV infection in patients with cervical lesions is significantly higher than that of normal people, and some couples are infected with the same HPV subtypes. Therefore, HPV testing and health education for spouses are beneficial to the prevention of cervical lesions.