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目的观察中药联合米非司酮治疗异位妊娠的临床疗效。方法将95例异位妊娠患者随机分为3组:治疗组33例口服米非司酮200 mg/d,连续3 d,并加服自拟宫外孕2号方;对照1组30例给予甲氨蝶呤50 mg/m~2单次肌肉注射;对照2组32例口服米非司酮200 mg/d,连续3 d。监测血β-HCG水平及包块变化情况,记录β-HCG降至正常和包块消失所需时间。结果治疗组治疗成功率为84.85%,与对照1组的83.33%比较差异无统计学意义(P>0.05),而与对照2组的62.50%比较差异有统计学意义(P<0.05)。治疗组β-HCG复常时间与对照1组差异无统计学意义,但短于对照2组(P<0.05);治疗组包块消失时间少于两对照组(P<0.05),且不良反应少于对照1组。结论米非司酮联合中药疗效与甲氨蝶呤相当,但不良反应较少。
Objective To observe the clinical efficacy of traditional Chinese medicine combined with mifepristone in the treatment of ectopic pregnancy. Methods 95 cases of ectopic pregnancy were randomly divided into three groups: the treatment group, 33 cases of oral mifepristone 200 mg / d, for 3 consecutive days, and served to conceive ectopic pregnancy on the 2nd party; control group 1 30 patients given methamidase A single intramuscular injection of pterin 50 mg / m ~ 2; control group 2 32 mifepristone 200 mg / d for 3 days. Blood β-HCG levels and changes in mass were monitored, and the time required for β-HCG to fall to normal and the mass to disappear was recorded. Results The success rate of treatment in treatment group was 84.85%, which was not significantly different from 83.33% in control group 1 (P> 0.05), but was significantly different from 62.50% in control group 2 (P <0.05). The time of β-HCG recovery in treatment group was not significantly different from that in control group 1, but shorter than that in control group 2 (P <0.05). The disappearance time of treatment group was less than that in control group (P <0.05) Less than control group 1. Conclusion The efficacy of mifepristone combined with traditional Chinese medicine is similar to that of methotrexate, but with fewer adverse reactions.