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[目的]评价亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性与食管癌易感性的关系。[方法]检索CNKI、Pubmed、ScienceDirect、Springer Link等数据库,获得有关MTHFRC677T基因多态性与食管癌易感性的关系的文献,剔除不符合要求的文献,然后应用Meta分析软件RevMan4.3对各研究原始数据进行统计处理,计算合并OR值及95%可信区间。[结果]按照纳入标准,共纳入系统评价的文献共有10个病例对照研究组,其中食管癌患者2162例,对照3114例,CT和TT基因型同CC基因型比较,OR值分别为1.47(95%CI:1.10～1.96)和1.60(95%CI:1.07～2.39),Z值分别为2.62和2.30,对应的P值分别为0.009和0.02。[结论]对目前相关研究结果的Meta分析显示,MTHFRC677T基因多态性与食管癌易感性之间存在相关,即携带MTHFR C677T杂合基因型(CT)及突变纯合基因型(TT)的个体发生食管癌的危险性较高。
[Objective] To evaluate the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and susceptibility to esophageal cancer. [Methods] The databases of CNKI, Pubmed, ScienceDirect and Springer Link were searched to get the literature about the relationship between MTHFRC677T gene polymorphism and the susceptibility to esophageal cancer. Excluding the unqualified literature, we used Meta analysis software RevMan4.3 to study the relationship between MTHFRC677T polymorphism and esophageal cancer susceptibility. The original data were statistically processed and the combined OR and 95% confidence intervals were calculated. [Results] According to the inclusion criteria, a total of 10 case-control study groups were enrolled in the systematic reviews, of which 2162 were esophageal cancer patients and 3114 were controls. The CT and TT genotypes were significantly different from CC genotypes (OR = 1.47, 95 % CI: 1.10-1.96) and 1.60 (95% CI: 1.07-2.39) with Z values of 2.62 and 2.30, respectively, with corresponding P values of 0.009 and 0.02, respectively. [Conclusion] Meta-analysis of the current research results shows that MTHFRC677T gene polymorphism is associated with the susceptibility to esophageal cancer, that is, individuals carrying MTHFR C677T heterozygote (CT) and mutation homozygous (TT) The risk of esophageal cancer is higher.