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目的阐明幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）在功能性消化不良（ＦＤ）中的发病地位．方法对６７例Ｈｐ阳性和２９例Ｈｐ阴性ＦＤ患者胃窦部粘膜组织学病变（粘膜炎症、粘膜微血管损伤、粘膜萎缩和肠上皮化生）做对比分析．结果Ｈｐ阳性患者胃窦部粘膜组织学病变较Ｈｐ阴性者显著（Ｐ＜００５）．结论Ｈｐ对ＦＤ的发病具有重要作用，推想根治Ｈｐ可能会对Ｈｐ阳性的ＦＤ患者粘膜组织学病变的好转有益．
Objective To clarify the pathogenesis of Helicobacter pylori (Hp) in functional dyspepsia (FD). Methods The histopathological changes (mucosal inflammation, mucosal microvascular injury, mucosal atrophy and intestinal metaplasia) in gastric mucosa of 67 Hp positive patients and 29 Hp negative FD patients were analyzed. Results The histopathological changes of gastric mucosa in Hp-positive patients were significantly lower than those in Hp-negative patients (P <005). Conclusions Hp plays an important role in the pathogenesis of FD. Suppose that radical Hp may be beneficial to the improvement of mucosal histological changes in Hp-positive FD patients.