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目的探讨肿瘤坏死因子（ＴＮＦ）和白细胞介素１（ＩＬ－１）对室旁核神经元发育的影响。方法４０只出生后２４ｈ的小鼠颅内直接注射ＴＮＦ和ＩＬ－１，饲养至１周龄和１月龄时，用组织学方法观察室旁核神经元的形态特征、核团构筑及神经元分类情况。结果１周龄ＴＮＦ低浓度组和ＩＬ－１组室旁核区清晰，核区内大型神经元多，核周质内可见深紫色的尼氏体，１月龄时各组间无明显的区别。结论ＴＮＦ和ＩＬ－１能调节神经元发育，促进室旁核成熟期大型神经元数量的存留
Objective To investigate the effects of tumor necrosis factor (TNF) and interleukin-1 (IL-1) on the development of paraventricular nucleus neurons. Methods Forty mice were injected intracranially with TNF and IL-1 intracranially at 24 h after birth. The animals were maintained at 1 week and 1 month of age. Morphology, nucleus construction and neurons of paraventricular nucleus Classification situation. Results The 1-week TNF low concentration group and the IL-1 group had a clear paraventricular nucleus with many large neurons in the nucleus and deep purple Nissl body in the perinuclear area. There was no significant difference between the groups at 1 month . Conclusion TNF and IL-1 can regulate the development of neurons and promote the survival of large neurons in paraventricular nucleus