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在去除外周化学感受器的动物上,吸入低氧气体可以导致通气抑制反应,这一现象被认为与体内内啡肽系统有关。本实验旨在观察地塞米松处理和吗啡处理对低氧呼吸抑制的影响。实验在乌拉坦和氯醛糖混合麻醉的兔中进行,静脉注射三碘季铵酚麻痹肌肉,人工通气,切断静动脉窦神经和迷走神经,记录隔神经放电.实验同时监测股动脉血压和动脉氧和二氧化碳分压。用地塞米松预处理,反馈性的抑制垂体释放ACTH和β-内啡肤后,对低氧通气抑制反应无明显的影响;钾离子透析法观察动物形成急性吗啡耐受后,低氧和静脉注射吗啡所致的呼吸抑制效应则大大消弱甚至消失。
In animals with peripheral chemoreceptors, inhalation of hypoxic gases can lead to an airway suppression response, a phenomenon considered to be related to the endorphin system in vivo. This experiment aimed to observe the dexamethasone treatment and morphine treatment on hypoxia respiratory depression. Experiments were conducted in rabbits mixed with uralin and chloralose anesthesia, iv triiodide quaternary ammonium phenol paralysis muscle, artificial ventilation, transection of the transsphenoidal nerve and vagus nerve and recording of nerve transection.Meanwhile, the femoral artery blood pressure and arterial oxygen And partial pressure of carbon dioxide. Pretreatment with dexamethasone and feedback inhibition of pituitary release of ACTH and β-endorphin had no significant effect on hypoxia-induced inhibition. After acute morphine tolerance was observed by potassium ion dialysis, hypoxia and intravenous injection The respiratory depression caused by morphine greatly diminishes or even disappears.