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目的:探讨 C 反应蛋白(C-reactive protein,CRP)作为系统性炎症因子在老年人颈动脉硬化中的改变及其意义。方法:选取经超声多普勒确诊的颈动脉硬化病人共130例,根据狭窄程度分为重组54例,轻组76例,对照组为经超声多普勒证实无颈动脉硬化病变的健康人,共45例。采用放射比浊法测定血清 CRP、放射免疫法测定血清白细胞介素-6(IL-6)浓度。结果:颈动脉硬化组血清 CRP 水平显著高于对照组(P<0.01);在颈动脉硬化患者中,重组血清 CRP 水平显著高于轻组(P<0.01),但两组间 IL-6浓度无显著差异(P>0.05)。结论:血清 CRP、IL-6水平在颈动脉硬化患者中明显升高,CRP 浓度与颈动脉狭窄程度密切相关。
Objective: To investigate the significance and significance of C-reactive protein (CRP) as a systemic inflammatory cytokine in the elderly with carotid atherosclerosis. Methods: A total of 130 patients with carotid atherosclerosis diagnosed by ultrasound Doppler were selected. According to the degree of stenosis, 54 cases were reorganized and 76 cases were light. The control group was healthy people confirmed by Doppler ultrasound without carotid atherosclerosis. A total of 45 cases. Serum CRP levels were measured by nephelometry and serum interleukin-6 (IL-6) levels by radioimmunoassay. Results: Serum CRP level in carotid atherosclerosis group was significantly higher than that in control group (P <0.01). In patients with carotid atherosclerosis, CRP level in recombinant serum was significantly higher than that in mild group (P <0.01), but IL-6 concentration No significant difference (P> 0.05). Conclusion: Serum levels of CRP and IL-6 are significantly increased in patients with carotid atherosclerosis, CRP concentration is closely related to the degree of carotid stenosis.