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测定了NTMP(次氮三亚甲基膦酸),HEDTMP(N (羟乙基)乙二胺基三亚甲基膦酸),DCTMP(1,2 环己二胺四亚甲基膦酸),EDTMP(乙基二胺基四亚甲基膦酸),DTPMP(二乙基三胺基五亚甲基膦酸)的153Sm配合物以及HEDTMP,EDTMP,DTPMP的113,117Snm配合物在正辛醇 水中的表观脂水分配系数和在0 5%牛血清白蛋白(BSA)水溶液中与BSA的结合率。结果表明,这些配合物在正辛醇 水中的相对表观脂水分配系数和在BSA水溶液中与BSA的相对结合率呈线性正相关。两者之间的线性关系为这类配合物脂水分配系数的预测提供了一种新方法,同时也表明,在金属配合物与BSA的结合过程中,疏水作用力起着重要作用。
NTMP (nitrilotrismethylene phosphonic acid), HEDTMP (N (hydroxyethyl) ethylenediamine trimethylene phosphonic acid), DCTMP (1,2 cyclohexanediamine tetramethylene phosphonic acid), EDTMP (Ethyldiaminotetramethylene phosphonic acid), 153 Sm complex of DTPMP (diethyltriaminopentamethylenephosphonic acid), and 113,117Snm complex of HEDTMP, EDTMP, DTPMP in n-octanol water Apparent lipid water partition coefficient and BSA binding rate in 0 5% bovine serum albumin (BSA) aqueous solution. The results showed that the relative apparent lipid-water partition coefficients of these complexes in n-octanol water were positively correlated with the relative binding rates of BSA in aqueous BSA solution. The linear relationship between the two provides a new method for predicting the lipid-water partition coefficients of these complexes, and also shows that the hydrophobic interaction plays an important role in the binding of metal complexes to BSA.