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目的 研究内关穴位刺激对抗模拟失重大鼠心功能变化的作用,探索对抗失重环境下生理学变化的新措施.方法 采用尾部悬吊模拟失重生理效应.大鼠随机分成3组:对照组(Con),尾吊30天组(TS),尾吊30天加内关穴位隔日刺激组(TS+ neiguan),每组10只大鼠.结果 与Con组比,TS组和TS+ neiguan大鼠空腹体重明显下降(P＜0.05).超声心动图指标TS组室间隔舒张末期厚度(IVSd)、室间隔收缩末期厚度(IVSs)、左室短轴缩短率(FS)、左室舒张末期后壁厚度(LVPWd)下降(P＜0.05);左室舒张末期内径(LVDd)和左室射血分数(EF)显著下降(P＜0.01);心率(HR)显著升高.穴位刺激组尽管所有指标有类似于TS组的变化趋势,但与Con组相比,差别无统计学意义,且TS+neiguan组LVDd明显高于TS组(P＜0.01).去甲肾上腺素(NE)和肾上腺素(EPI)含量TS大鼠均明显高于对照组(P＜0.01)和TS+ neiguan组(P＜0.05);TS+neiguan与Con组比无明显差别.血清血管紧张素Ⅱ(AngⅡ)和皮质酮(CORT)含量各组间无差别.醛固酮(ALD)含量TS组和TS+neiguan组明显高于Con组(P ＜0.05,P＜0.01).结论 模拟失重主要引起左心室功能降低和结构变化,心血管调节功能变化,内关穴位刺激能较好对抗这些不利影响,在对抗失重生理变化方面可能有较好应用前景.“,”Objective To research the effects of neiguan acupoint stimulation on the cardiac tunctional changes in simulated weightlessness rats and explore the new countermeasure against cardiac functional changes in weightlessness environment.Methods-30° tail suspended rats were used as the model to simulate the physiological effects of weightlessness.Wistar rats were randomly arranged into:control group(Con,n =10),tailsuspension group(TS,n =10) and TS + neiguan group(TS + neiguan,n =10).TS and TS + neiguan were suspended for 30 days,and TS + neiguan was yet stimulated in neiguan acupoint per two days.Results Compared with Con,the body weight in TS and TS + neiguan rats decreased significantly(P ＜ 0.05).About echocardiographic indexes:TS compared with Con,the interventricular septum of the end-diastole (IVSd),the interventricular septum of the end-systole(IVSs),fraction shortening(FS) and the left ventricular posterior wall of end-diastole(LVPWd) decreased (P ＜ 0.05),the left ventricular dimension of end-diastole (LVDd) and ejection fraction(EF) decreased significantly (P ＜ 0.01),the heart rate (HR) increased (P ＜ 0.05).TS + neiguan was the similar trend as TS but no significant difference as compared with Con,otherwise the LVDd increased very significantly(P ＜0.01) as compared with TS.It was showed neiguan stimulation ameliorating cardiac function of TS rats.Compared with Con and TS + neiguan rats,the noradrenaline (NE) and epinephrine(EPI) in TS increased significantly(P ＜0.01,P ＜0.05),as well as these indexes in the TS + neiguan rats had no statistical difference as compared with Con.There was no difference in angiotension Ⅱ (Ang Ⅱ) and corticosterone(CORT) among 3 groups.Compared with Con,serum aldosterone(ALD) concentration increased in TS (P ＜ 0.05) and TS + neiguan (P ＜ 0.01).Conclusion Simulated weightlessness mainly results in decrease of the left ventricular function,cardiac structural and cardiovascular regulatory changes,and neiguan acupoint stimulation may alleviate these disadvantageous influence and may have a good foreground in countermining the cardiac functional changes in weightlessness environment.