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目的探讨多重对应分析(multiple correspondence analysis,MCA)方法在评价氟暴露与男性不育关系中的应用。方法 2010—2011年调查贵州省208例农村男性居民的用煤情况、氟斑牙情况及生育情况,整理成三维列联表,采用MCA分析其生育情况及用煤情况、炉灶改良、氟斑牙程度等之间的关系。结果 MAC关联图显示,牙齿正常、不常用煤同在第一象限且距离很近,即在很少用煤的家庭也很少见到氟斑牙,说明该地氟斑牙与燃煤型氟暴露有关;已生育且曾流产独在第二象限;常用煤但炉灶改良、轻度及以下氟斑牙、已生育且无流产同在第三象限,说明氟暴露较轻的人群生育能力一般改变不明显,流产的可能性也较低;中度重度氟斑牙、从未妊娠过、常用煤且炉灶未改良、未生育但曾妊娠同在第四象限且相隔较近,反映出氟暴露严重的人群生育不正常甚至不育的可能性更高。结论该省部分男性村民的生育情况与其用煤情况、氟斑牙程度等因素有较强的对应关系,提示高氟暴露为男性不育的危险因素。MCA能直观展示氟暴露与生育情况等变量间的联系,可作为病因探索的重要工具。
Objective To explore the application of multiple correspondence analysis (MCA) in evaluating the relationship between fluoride exposure and male infertility. Methods From 2010 to 2011, the coal use conditions, dental fluorosis and fertility of 208 rural male residents in Guizhou Province were surveyed to make a three-dimensional contingency table. The MCA was used to analyze the fertility and coal use conditions, stove improvement, dental fluorosis The relationship between the degree and so on. Results The MAC correlation diagram showed that the teeth were normal and the infrequently used coal was close to the first quadrant, that is, the dental fluorosis was seldom seen in the families with little coal, indicating that the dental fluorosis and the coal-burning fluorine Exposed; have been born and had abortion in the second quadrant; common coal but stove improvement, mild and below dental fluorosis, has been born with no abortion in the third quadrant, indicating that fluoride exposure to the general population changes in fertility change Not obvious, the possibility of miscarriage is also low; moderate to severe dental fluorosis, never pregnant, commonly used coal and stove unimproved, did not give birth but had the same with the fourth quadrant of pregnancy and close, reflecting the serious fluoride exposure Of the population is more likely to have abnormal or even infertility. Conclusion The fertility of some male villagers in this province has a strong correspondence with the use of coal and the degree of dental fluorosis, suggesting that high fluoride exposure is a risk factor for male infertility. MCA can directly display the relationship between fluoride exposure and fertility variables and other variables, which can be used as an important tool to explore the cause.